Sauté ground beef, onion, garlic, and red pepper flakes in a large skillet until onion is tender and beef is lightly browned. Drain off excess fat. Add spaghetti sauce, and simmer 15 minutes.

Bring a large pot of lightly salted water to a boil. Add ziti pasta, and cook until al dente, about 8 minutes; drain.

Preheat the oven to 350 degrees F. Spray a 9×13 inch baking dish with cooking spray. Layer as follows: 1/2 of the ziti, sauce mixture, Provolone cheese, sour cream, sauce mixture, remaining ziti, sauce mixture, mozzarella cheese and grated Parmesan cheese.

Cover with foil and bake for 30 minutes in the preheated oven, or until cheeses are melted.